Huang Lab


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Publications

  • Huang B, Smith JL, Farrar JE, Wang YC, Umeda M, Ries RE, Leonti AR, Crowgey E, Furlan SN, Tarlock K, Armendariz M, Liu Y, Shaw TI, Wei L, Gerbing R, Cooper TM, Gamis AS, Aplenc R, Kolb EA, Rubnitz J, Ma J, Klco JM, Ma X, Alonzo TA, Triche T, Meshinchi S. Integrated stem cell signature and cytomolecular risk determination in pedaitric acute myeloid leukemia. Nature Communications. Accepted for publication.
  • Meyer LK, Delgado-Martin C, Sharp PP, Huang B, McMinn D, Vincent TL, Ryan T, Horton TM, Wood BL, Teachey DT, Taunton J, Kirk CJ, Hermiston ML. Inhibition of the Sec61 translocon overcomes cytokine-induced glucocorticoid reistance in T-cell acute lymphoblastic leukemia. Br J Haematol. 2022 Apr 17. doi: 10.1111/bjh.18181.
  • Umeda M, Ma J, Huang B, Hagiwara K, Westover T, Abdelhamed S, Barajas JM, Thomas ME, Walsh MP, Song G, Miller J, Hiltenbrand R, Liu Y, Chen X, Foy X, Iacobucci I, Kleist AB, Ries RE, Wu H, Rusch M, Alonzo TA, Maciaszek JL, Inaba H, Wu G, Valentine V, Valentine M, Liu YC, Mullighan CG, Pounds S, Babu MM, Zhang J, Rubnitz JE, Meshinchi S, Ma X, Klco JM. Integrated genomic analysis identifies UBTF tandem duplications as a recurrent lesion in pediatric acute myeloid leukemia. Blood Cancer Discov. 2022 Feb 16. doi: 10.1158/2643-3230.BCD-21-0160.
  • Huang B, Smith JL, Wang YC, Taghizadeh K, Leonti AR, Ries RE, Liu Y, Kolekar P, Tarlock K, Gerbing R, Crowgey EL, Furlan SN, Shaw TI, Hagiwara K, Wei L, Cooper TM, Gamis AS, Aplenc R, Kolb EA, Farrar JE, Triche T, Alonzo TA, Ma X, Meshinchi S. CBFB-MYH11 Fusion Transcripts Distinguish Acute Myeloid Leukemias with Distinct Molecular Landscapes and Outcomes. Blood Adv. 2021 Sep 21; bloodadvances.2021004965.
  • Remsberg J, Suciu R, Zambetti N, Hanigan T, Firestone A, Inguva A, Long A, Ngo N, Lum K, Henry C, Richardson S, Predovic M, Huang B, Howell A, Niphakis M, Shannon K. ABHD17 enzymes regulate dynamic plasma membrane palmitoylation and N-Ras-dependent cancer growth. Nat Chem Biol. 2021 Apr 29. doi: 10.1038/s41589-021-00785-8.
  • Peretz C, McGary L, Kumar T, Jackson H, Jacob J, Durruthy-Durruthy R, Levis M, Perl A, Huang B, Smith C. Single cell DNA sequencing reveals complex mechanisms of resistance to quizartinib. Blood Adv. 2021 Mar 9;5(5):1437-1441.
  • Pucciarelli D, Angus SP, Huang B, Zhang C, Krishnamurthi G, Bandyopadhyay S, Clapp W, Shannon K, Johnson GL, Nakamura JL. Nf1 mutant tumors undergo transcriptome and kinome re-modeling after inhibition of either mTOR or MEK. Mol Cancer Ther. 2020 Aug 26;molcanther.1017.2019. doi: 10.1158/1535-7163.MCT-19-1017.
  • Zambetti NA, Firestone AJ, Remsberg JR, Huang B, Wong JC, Long AM, Predovic M, Suciu RM, Inguva A, Kogan SC, Haigis KM, Cravatt BF, Shannon K. Genetic disruption of palmitoylation abrogates hematopoietic transformation by NrasG12D in vivo. Blood. 2020 May 14;135(20):1772-1782.
  • Wandler AM, Huang B, Craig J, Hayes K, Yan H, Meyer LK, Scacchetti A, Monsalve G, Dail M, Li Q, Wong JC, Weinberg O, Hasserjian RP, Kogan SC, Yamamoto K, Sampath D, Nakitandwe J, Downing JR, Zhang J, Aster JC, Taylor BS, and Shannon K. Loss of glucocorticoid receptor expression mediates in vivo dexamethasone resistance in T-cell acute lymphoblastic leukemia. Leukemia. 2020 Aug;34(8):2025-2037.
  • Meyer LK, Huang B, Delgado-Martin C, Roy R, Hechmer A, Wandler AM, Vincent TL, Olshen A, Wood BL, Horton TM, Shannon KM, Teachey DT, Hermiston ML. Glucocorticoids paradoxically facilitate steroid resistance in T-cell acute lymphoblastic leukemias. J Clin Invest. 2020 Jan 13. pii: 130189.
  • Huang B, Wandler A, Meyer L, Dail M, Daemen A, Sampath D, Li Q, Wang X, Wong JC, Nakitandwe J, Downing JR, Zhang J, Taylor B, Shannon K. Convergent Genetic Aberrations in Murine and Human T Lineage Acute Lymphoblastic Leukemias. PLoS Genet. 2019 Jun 14;15(6):e1008168.
  • Delgado-Martin C, Meyer LK, Huang B, Shimano KA, Zinter MS, Nguyen JV, Smith GA, Taunton J, Winter SS, Roderick JR, Kelliher MA, Horton TM, Wood BL, Teachey DT, Hermiston ML. JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias. Leukemia. 2017 May 9. doi: 10.1038/leu.2017.136.
  • Burgess MR, Hwang E, Mroue R, Bielski CM, Wandler AM, Huang B, Firestone AJ, Young A, LaCap J, Crocker L, Asthana S, Davis EM, Xu J, Akagi K, Le Beau MM, Li Q, Stokoe D, Sampath D, Taylor BS, Evangelista M, Shannon K. KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer. Cell. 2017 Feb 23;168(5):817-829.e15.
  • Dail M, Li Q, McDaniel A, Wong J, Akagi K, Huang B, Kang HC, Kogan SC, Shokat K, Wolff L, Braun BS, Shannon K. Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T-lineage leukemogenesis and modulate responses to targeted agents. Proc Natl Acad Sci. 2010 Mar 16;107(11):5106-11.

Selected Abstracts

  • Huang B, Smith JL, Shaw TI, Furlan SN, Ries RE, Leonti AR, Crowgey EL, Wei L, Farrar JE, Trich T, Ma X, Le Q, Meshinchi S. Integrated Transcriptomics and Proteomics Identifies Therapeutic Targets in Pediatric Acute Myeloid Leukemia. Blood (American Society of Hematology Annual Meeting), 2021.
  • Huang B, Wang X, Harris M, Wandler A, Hwang E, Burgess MR, Li Q, Severson P, Powell B, Kolb EA, Meshinchi S, Taylor BS, Bollag G, Shannon K. Co-Targeting BET Bromodomain Proteins and Aberrant Signaling in AML. Blood (American Society of Hematology Annual Meeting), 2020.